| Date | Age | Event | Bishop | Title | Current Title |
| 3 Sep 2020 | 66.3 | Installed | Gonzalo de Villa y Vásquez, S.J. | Archbishop of Santiago de Guatemala |
| 77.3 | Ceased | Raúl Antonio Martinez Paredes | Apostolic Administrator of Santiago de Guatemala | Auxiliary Bishop Emeritus |
| 4 Sep 2020 | 42.9 | Appointed | Tulio Omar Pérez Rivera | Administrator of Sololá-Chimaltenango | Auxiliary Bishop of Santiago de Guatemala |
| 11 Jan 2021 | 59.6 | Appointed | Bernabé de Jesús Sagastume Lemus, O.F.M. Cap. | Bishop of San Marcos |
| 25 Mar 2021 | 59.8 | Installed | Bernabé de Jesús Sagastume Lemus, O.F.M. Cap. | Bishop of San Marcos |
| 27 Mar 2021 | 58.9 | Appointed | Juan Manuel Cuá Ajacum | Auxiliary Bishop of Los Altos, Quetzaltenango-Totonicapán | Bishop of Quiché |
| 58.9 | Appointed | Juan Manuel Cuá Ajacum | Titular Bishop of Rosella | Bishop of Quiché |
| 24 Jun 2021 | 59.1 | Ordained Bishop | Juan Manuel Cuá Ajacum | Titular Bishop of Rosella | Bishop of Quiché |
| 16 Jul 2021 | 58.5 | Appointed | Domingo Buezo Leiva | Bishop of Sololá-Chimaltenango |
| 70.8 | Appointed | José Cayetano Parra Novo, O.P. | Bishop of Santa Rosa de Lima |
| 21 Sep 2021 | 58.7 | Installed | Domingo Buezo Leiva | Bishop of Sololá-Chimaltenango |
| 78.3 | Appointed | Raúl Antonio Martinez Paredes | Apostolic Administrator of Izabal | Auxiliary Bishop Emeritus of Santiago de Guatemala |
| 44.0 | Ceased | Tulio Omar Pérez Rivera | Administrator of Sololá-Chimaltenango | Auxiliary Bishop of Santiago de Guatemala |
| 30 Sep 2021 | 71.0 | Installed | José Cayetano Parra Novo, O.P. | Bishop of Santa Rosa de Lima |
| 10 Oct 2021 | 74.2 | Installed | Alvaro Leonel Ramazzini Imeri | Cardinal-Priest of San Giovanni Evangelista a Spinaceto | Cardinal, Bishop of Huehuetenango |
| 17 Feb 2022 | 96.1 | Died | Gerardo Humberto Flores Reyes † | Bishop Emeritus of Verapaz, Cobán |
| 14 Mar 2022 | 92.4 | Died | José Ramiro Pellecer Samayoa † | Auxiliary Bishop Emeritus of Guatemala |
| 27 Jun 2022 | 44.7 | Appointed | Tulio Omar Pérez Rivera | Auxiliary Bishop of Santiago de Guatemala |
| 44.7 | Appointed | Tulio Omar Pérez Rivera | Titular Bishop of Filaca | Auxiliary Bishop of Santiago de Guatemala |
| 21 Sep 2022 | 45.0 | Ordained Bishop | Tulio Omar Pérez Rivera | Titular Bishop of Filaca | Auxiliary Bishop of Santiago de Guatemala |
| 23 Dec 2022 | 63.6 | Appointed | Miguel Ángel Martínez Méndez | Vicar Apostolic of Izabal |
| 18 Mar 2023 | 79.8 | Ceased | Raúl Antonio Martinez Paredes | Apostolic Administrator of Izabal | Auxiliary Bishop Emeritus of Santiago de Guatemala |
| 63.8 | Ordained Bishop | Miguel Ángel Martínez Méndez | Vicar Apostolic of Izabal |
| 15 Apr 2023 | 78.1 | Retired | Rosolino Bianchetti Boffelli | Bishop of Quiché | Bishop Emeritus |
| 60.9 | Appointed | Juan Manuel Cuá Ajacum | Bishop of Quiché |
| 22 May 2023 | 64.9 | Appointed | Nicolas Henry Marie Denis Thevenin | Apostolic Nuncio to Oman | Apostolic Nuncio to Egypt, Arab Republic of |
| 7 Jun 2023 | 80.0 | Retired | Raúl Antonio Martinez Paredes | Auxiliary Bishop of Santiago de Guatemala | Auxiliary Bishop Emeritus |
| 1 Jul 2023 | 61.1 | Installed | Juan Manuel Cuá Ajacum | Bishop of Quiché |
| 11 Jul 2023 | 75.0 | Retired | Bruno Musarò | Apostolic Nuncio to Costa Rica | Apostolic Nuncio |
| 27 Mar 2024 | 53.7 | Appointed | Eddy René Calvillo Díaz | Auxiliary Bishop of Santiago de Guatemala |
| 53.7 | Appointed | Eddy René Calvillo Díaz | Titular Bishop of Carmeiano (Cameiano) | Auxiliary Bishop of Santiago de Guatemala |
| 22 Jun 2024 | 53.9 | Ordained Bishop | Eddy René Calvillo Díaz | Titular Bishop of Carmeiano (Cameiano) | Auxiliary Bishop of Santiago de Guatemala |
| 20 Aug 2024 | 83.4 | Died | Ramiro Moliner Inglés † | Apostolic Nuncio |
| 21 Oct 2024 | 87.3 | Died | Giovanni Battista Morandini † | Apostolic Nuncio |
| 10 Dec 2024 | 76.1 | Retired | Mario Alberto Molina Palma, O.A.R. | Archbishop of Los Altos, Quetzaltenango-Totonicapán | Archbishop Emeritus |
| 66.6 | Appointed | Victor Hugo Palma Paúl | Archbishop of Los Altos, Quetzaltenango-Totonicapán |
| 22 Feb 2025 | 66.8 | Installed | Victor Hugo Palma Paúl | Archbishop of Los Altos, Quetzaltenango-Totonicapán |