| Date | Age | Event | Bishop | Title | Current Title |
| unknown | | Appointed | Tommaso Albini (Albizi), O.P. † | Bishop of Cagli, Italy | Titular Bishop of Bethleem |
| Born | Philibert Babou de La Bourdaisičre † | | Cardinal, Bishop Emeritus of Angoulęme, France |
| Born | Guillaume de Barton † | | Bishop Emeritus of Lectoure, France |
| 38.0 | Appointed | Péter (Petar) Beriszló (Berislavić) † | Bishop of Veszprém, Hungary |
| Died | Giacomo Biagioli † | Bishop of Senj, Croatia |
| Born | Bernardino Bricennio (Brisseno) † | | Bishop of Vigevano, Italy |
| Resigned | Joăo Camelo de Madureira, O.S.A. † | Bishop of Lamego, Portugal | Bishop Emeritus |
| Born | Giovanni Campeggi † | | Bishop of Bologna, Italy |
| Born | Pietro Antonio Di Capua † | | Archbishop of Otranto, Italy |
| 44.0 | Died | Giovanni Giacomo Castiglione † | Archbishop of Bari (-Canosa), Italy |
| Resigned | Tommaso Catanei, O.P. † | Bishop of Cervia, Italy | Bishop Emeritus |
| Died | Michele Claudio † | Bishop of Monopoli, Italy |
| Died | Thomas Cornish, O.S. Jean de Jér † | Auxiliary Bishop of Exeter, England, Great Britain |
| Died | Bernardino da Bologna † | Archbishop of Messina, Italy |
| Resigned | Raffaele di Ceva, O.F.M. † | Bishop of Melfi, Italy | Bishop Emeritus |
| Resigned | Charles du Hautbois † | Bishop of Tournai {Doornik}, Belgium | Bishop Emeritus |
| Born | Francisco da Cruz, O.S.A. † | | Bishop Emeritus of Santiago de Cabo Verde |
| Died | Albertino della Rovere † | Bishop of Pesaro, Italy |
| 27.0 | Resigned | Thomas de Foix † | Bishop-Elect of Tarbes, France | Former Bishop-Elect |
| Died | Alfonso Galieto, O.S.A. † | Bishop of Castellaneta, Italy |
| Died | György , O.S.B. † | Bishop of Trebinje e Mrkan, Bosnia and Herzegovina |
| Born | Antoine Havet, O.P. † | | Bishop of Namur {Namen}, Belgium |
| Appointed | Höskuld Höskuldsson † | Bishop of Stavanger, Norway |
| Died | Jean † | Bishop of Orange, France |
| Died | Edward Lane † | Bishop of Kildare, Ireland |
| Appointed | Martin Le Doux Bailliaux, O.F.M. † | Bishop of Arkadi, Greece | Titular Bishop of Bethleem |
| Resigned | Camillo Leonini † | Bishop of Tivoli, Italy |
| Appointed | Imbert de la Platičre de Bourdillon † | Bishop of Nevers, France |
| Born | Mathurin de la Saussaye † | | Bishop of Orléans, France |
| Born | Giacomo Luccari, O.F.M. Obs. † | | Bishop of Trebinje e Mrkan, Bosnia and Herzegovina |
| Died | Giorgio Maccafano de’ Pireto † | Bishop of Sarno, Italy |
| Appointed | Mogens Lauritsson † | Bishop of Hamar, Norway |
| Died | Tommaso Malumbra † | Bishop of Stagno (Ston) et Curzola (Korcula), Croatia |
| 53.0 | Installed | Alonso Manso † | Bishop of Puerto Rico (Porto Rico) |
| Born | Alfonso Merchante de Valeria † | | Auxiliary Bishop of Burgos, Spain |
| Born | Alvise Michiel † | | Archbishop of Split (Spalato), Croatia |
| Died | Giorgio Negri † | Bishop of Lezhë {Lesh, Alessio}, Albania |
| Succeeded | Nicolň Niconisi † | Bishop of Stagno (Ston) et Curzola (Korcula), Croatia |
| Died | Andrea Novelli † | Bishop of Alba (Pompea), Italy |
| Born | Leone Orsini † | | Bishop of Fréjus, France |
| Died | Roberto Piscicelli † | Archbishop of Brindisi, Italy |
| Appointed | Albertus Polonus, O.P. † | Auxiliary Bishop of Halberstadt, Germany |
| Appointed | Albertus Polonus, O.P. † | Titular Bishop of Acre (or Ptolomais) | Auxiliary Bishop of Halberstadt, Germany |
| Appointed | Richard † | Auxiliary Bishop of Durham, England, Great Britain |
| Appointed | Richard † | Titular Bishop of Athyra | Auxiliary Bishop of Durham, England, Great Britain |
| Died | Angelo Ripanti † | Bishop of Jesi, Italy |
| Appointed | Giorgio Benigno Salviati, O.F.M. † | Titular Archbishop of Nazareth |
| Appointed | Girolamo de Sanctis, O.S.A. † | Bishop of Argos, Greece |
| Appointed | Luca de Seriate (Seriago) † | Titular Bishop of Duvno, Bosnia and Herzegovina | Auxiliary Bishop of Cremona, Italy |
| Died | Giovanni Maria Sforza Visconti † | Archbishop of Genova, Italy |
| Born | Diego de Simancas † | | Bishop of Zamora, Spain |
| 57.0 | Appointed | Georg von Slatkonia † | Bishop of Pedena, Austria | Bishop of Wien, Austria |
| Appointed | Roger Smith † | Auxiliary Bishop of Lincoln, England, Great Britain |
| Appointed | Roger Smith † | Titular Bishop of Lydda | Auxiliary Bishop of Lincoln, England, Great Britain |
| Born | Balthasar Wurer † | | Auxiliary Bishop Emeritus of Konstanz {Constance}, Germany |
| 7 Jan | | Appointed | Richard Barrett † | Bishop of Killala, Ireland |
| 9 Jan | | Ordained Bishop | Imbert de la Platičre de Bourdillon † | Bishop of Nevers, France |
| 23 Jan | | Born | Sebastiano Gualterio † | | Bishop of Viterbo e Tuscania, Italy |
| Feb | | Died | Pedro López Ayala † | Bishop of Islas Canarias {Canary Islands}, Spain |
| 3 Feb | 52.0 | Died | Philipp von Rosenberg † | Bishop of Speyer, Germany |
| 6 Feb | | Ordained Bishop | István Podmanický † | Bishop of Nitra, Slovakia |
| 9 Feb | | Died | George Hepburn, O.S.B. † | Bishop of The Isles (Sodor), Scotland, Great Britain |
| 11 Feb | | Died | Dafydd (David) ab Owain (Owen), O. Cist. † | Bishop of Saint Asaph, Wales, Great Britain |
| 12 Feb | 27.0 | Selected | Georg von Rhein (Bayern) † | Bishop of Speyer, Germany |
| 14 Feb | | Died | Juan de Enguera, O.P. † | Bishop of Tortosa, Spain |
| 21 Feb | 69.2 | Died | Giuliano della Rovere † | Pope (Roma {Rome}, Italy) |
| 9 Mar | 37.2 | Elected | Giovanni de’ Medici † | Pope (Roma {Rome}, Italy) |
| 15 Mar | 37.2 | Ordained Priest | Giovanni de’ Medici † | Priest | Pope (Roma {Rome}, Italy) |
| 17 Mar | 37.2 | Ordained Bishop | Giovanni de’ Medici † | Pope (Roma {Rome}, Italy) |
| 18 Mar | 25.5 | Appointed | Giovanni Maria Ciocchi del Monte † | Archbishop of Manfredonia, Italy | Pope (Roma {Rome}, Italy) |
| 19 Mar | | Appointed | Juan Castellanos de Villalba † | Bishop of Elne, France | Bishop of Calahorra y La Calzada, Spain |
| 31.2 | Appointed | Marco Cornaro † | Cardinal-Deacon of Santa Maria in Via Lata | Cardinal, Cardinal-Bishop of Palestrina |
| Appointed | Giovanni de’ Capellani † | Bishop of Bovino, Italy |
| 37.2 | Installed | Giovanni de’ Medici † | Pope (Roma {Rome}, Italy) |
| 85.2 | Resigned | Jaime Serra i Cau † | Administrator of Elne, France | Cardinal, Cardinal-Bishop of Palestrina |
| Appointed | Albert de Sylva † | Titular Bishop of Sebaste in Cilicia |
| 22 Mar | 38.5 | Appointed | Luigi d’Aragona † | Administrator of Cava (de’ Tirreni), Italy | Cardinal, Administrator of Nardň, Italy |
| 23 Mar | | Died | Gottschalk Hagen † | Bishop of Reval (Rewel), Estonia |
| 25 Mar | 53.2 | Died | Maurice O’Fihely, O.F.M. † | Archbishop of Tuam, Ireland |
| 4 Apr | 22.7 | Ordained Priest | Albrecht von Brandenburg † | Priest of Lebus, Germany | Cardinal, Archbishop of Mainz, Germany |
| 53.2 | Appointed | Paride de Grassis † | Bishop of Pesaro, Italy |
| Appointed | Etienne † | Titular Bishop of Rheon |
| Appointed | Gaspar Ponz † | Bishop of Catania, Italy |
| 6 Apr | 49.2 | Appointed | Johannes Petrus Brask † | Bishop of Linköping, Sweden |
| Appointed | Marco Antonio Prioldo † | Bishop of Castellaneta, Italy |
| 85.2 | Resigned | Jaime Serra i Cau † | Administrator of Linköping, Sweden | Cardinal, Cardinal-Bishop of Palestrina |
| 9 Apr | 46.3 | Died | Cosimo de’ Pazzi † | Archbishop of Firenze {Florence}, Italy |
| Appointed | Teodoro de Piis, O.F.M. † | Bishop of Monopoli, Italy |
| 12 Apr | | Died | Charles de Seyssel † | Bishop of Genčve {Geneva}, Switzerland |
| 14 Apr | 50.2 | Appointed | John Young † | Auxiliary Bishop of London, England, Great Britain |
| 50.2 | Appointed | John Young † | Titular Bishop of Callipolis | Auxiliary Bishop of London, England, Great Britain |
| 16 Apr | | Appointed | Raymond (Edmund) Birkhead, O.F.M. † | Bishop of Saint Asaph, Wales, Great Britain |
| 17 Apr | | Ordained Bishop | Roger Smith † | Titular Bishop of Lydda | Auxiliary Bishop of Lincoln, England, Great Britain |
| 18 Apr | 34.2 | Appointed | Denis Briçonnet † | Bishop of Saint-Malo, France |
| 22 Apr | | Appointed | Martín Laleza † | Titular Bishop of Albanen |
| 24 Apr | 28.3 | Ordained Bishop | Paweł Algimunt Holszański † | Bishop of Lutsk (Łuck), Ukraine | Bishop of Vilnius, Lithuania |
| May | | Resigned | Pietro Carlo † | Bishop of Caorle, Italy | Bishop Emeritus |
| 9 May | 34.9 | Appointed | Giulio de’ Medici † | Archbishop of Firenze {Florence}, Italy | Pope (Roma {Rome}, Italy) |
| Died | Menelaus MacCarmacan † | Bishop of Raphoe, Ireland |
| 41.3 | Appointed | Esteban Gabriel Merino † | Archbishop of Bari (-Canosa), Italy | Cardinal, Patriarch of West Indies, Spain |
| Appointed | Paul de Naghievic † | Titular Bishop of Callipolis |
| Appointed | Michele di Natera, O.P. † | Bishop of Lezhë {Lesh, Alessio}, Albania |
| Appointed | Daniel Rossi † | Bishop of Caorle, Italy | Bishop Emeritus |
| 67.3 | Resigned | Marco Vigerio della Rovere, O.F.M. Conv. † | Bishop of Senigallia, Italy | Cardinal, Archbishop of Trani, Italy |
| 11.3 | Appointed | Marco Quinto Vigerio della Rovere † | Bishop of Senigallia, Italy |
| 16 May | 53.3 | Ordained Bishop | Paride de Grassis † | Bishop of Pesaro, Italy |
| Appointed | Hugo Heskart † | Bishop of The Isles (Sodor), Scotland, Great Britain |
| 18 May | | Appointed | Giosuč de Gaeta † | Bishop of Ascoli Satriano (Puglia), Italy | Bishop Emeritus |
| 20 May | | Appointed | Thomas Hulsay † | Bishop of Leighlin, Ireland |
| 69.3 | Appointed | Luis Mercader Escolano, O. Cart. † | Bishop of Tortosa, Spain |
| Appointed | Fernando Vázquez de Arce † | Bishop of Islas Canarias {Canary Islands}, Spain |
| 29 May | | Ordained Bishop | Raymond (Edmund) Birkhead, O.F.M. † | Bishop of Saint Asaph, Wales, Great Britain |
| Jun | 58.5 | Appointed | Carlo Domenico del Carretto † | Cardinal-Priest of Santa Cecilia | Cardinal, Bishop Emeritus of Cahors, France |
| Died | Ottaviano Spinelli del Palagio † | Archbishop of Armagh, Ireland |
| 8 Jun | | Appointed | Luis González, O.F.M. Obs. † | Bishop of Ampurias e Civita, Italy |
| 22.4 | Appointed | Louis Guillart † | Bishop of Tournai {Doornik}, Belgium | Bishop Emeritus of Senlis, France |
| Appointed | Domingo Idiocáiz † | Archbishop of Brindisi, Italy |
| 15 Jun | | Appointed | Antonio Balestrieri, O. Cist. † | Archbishop of Amalfi, Italy | Archbishop Emeritus |
| 17 Jun | | Died | Battista Del Bufalo † | Bishop of Aquino, Italy |
| 19 Jun | | Ordained Bishop | Höskuld Höskuldsson † | Bishop of Stavanger, Norway |
| 22 Jun | | Appointed | Martin Le Doux Bailliaux, O.F.M. † | Titular Bishop of Bethleem |
| 51.4 | Appointed | Francesco de Remolins † | Administrator of Sarno, Italy | Cardinal, Cardinal-Bishop of Albano |
| 27.3 | Confirmed | Georg von Rhein (Bayern) † | Bishop of Speyer, Germany |
| 27 Jun | 56.8 | Appointed | Bernardino López de Carvajal y Sande † | Bishop of Sigüenza, Spain | Cardinal, Cardinal-Bishop of Ostia (e Velletri) |
| 56.8 | Appointed | Bernardino López de Carvajal y Sande † | Cardinal-Bishop of Sabina | Cardinal, Cardinal-Bishop of Ostia (e Velletri) |
| 56.8 | Appointed | Bernardino López de Carvajal y Sande † | Titular Patriarch of Jerusalem {Gerusalemme}, Palestine | Cardinal, Cardinal-Bishop of Ostia (e Velletri) |
| 60.0 | Appointed | Francesco Soderini † | Cardinal-Bishop of Tivoli, Italy | Cardinal, Cardinal-Bishop of Ostia (e Velletri) |
| Appointed | Pierre Tallon, O.F.M. † | Bishop of Sapë, Albania |