| Date | Age | Event | Bishop | Title | Current Title |
|---|
| 24 Feb 2025 | 51.4 | Appointed | Eloy Alberto Santiago Santiago | Bishop of San Cristóbal de La Laguna o Tenerife |
| 1 Mar 2025 | 80.0 | Retired | Fernando Vérgez Alzaga, L.C. | President of the Governatorate of Vatican City State | Cardinal, President Emeritus of the Pontifical Commission for Vatican City State |
| 80.0 | Retired | Fernando Vérgez Alzaga, L.C. | President of the Pontifical Commission for Vatican City State | Cardinal, President Emeritus |
| 6 Mar 2025 | 56.6 | Appointed | Ángel Román Idígoras | Bishop of Albacete |
| 19 Mar 2025 | 53.6 | Ordained Bishop | Diego Ramón Sarrió Cucarella, M. Afr. | Bishop of Laghouat, Algeria |
| 22 Mar 2025 | 65.7 | Appointed | Bernardito Cleopas Auza | Apostolic Nuncio to European Union |
| 27 Mar 2025 | 75.1 | Retired | Demetrio Fernández González | Bishop of Córdoba | Bishop Emeritus |
| 69.5 | Appointed | Jesús Fernández González | Bishop of Córdoba |
| 29 Mar 2025 | 67.7 | Appointed | Pedro Aguado Cuesta, Sch. P. | Bishop of Huesca |
| 67.7 | Appointed | Pedro Aguado Cuesta, Sch. P. | Bishop of Jaca | Bishop of Huesca |
| 21 Apr 2025 | 62.8 | Ceased | Alejandro Arellano Cedillo, C.O.R.C. | Dean of the Roman Rota |
| 65.3 | Ceased | Maximino Caballero Ledo | Prefect of the Secretariat for the Economy |
| 64.6 | Ceased | Ángel Fernández Artime, S.D.B. | Cardinal, Pro-Prefect of the Dicastery for Institutes of Consecrated Life and Societies of Apostolic Life |
| 1 May 2025 | 51.6 | Ordained Bishop | Eloy Alberto Santiago Santiago | Bishop of San Cristóbal de La Laguna o Tenerife |
| 2 May 2025 | 79.2 | Died | Esteban Escudero Torres † | Auxiliary Bishop Emeritus of Valencia |
| 3 May 2025 | 56.8 | Ordained Bishop | Ángel Román Idígoras | Bishop of Albacete |
| 9 May 2025 | 62.9 | Confirmed | Alejandro Arellano Cedillo, C.O.R.C. | Dean of the Roman Rota |
| 65.3 | Confirmed | Maximino Caballero Ledo | Prefect of the Secretariat for the Economy |
| 64.7 | Confirmed | Ángel Fernández Artime, S.D.B. | Cardinal, Pro-Prefect of the Dicastery for Institutes of Consecrated Life and Societies of Apostolic Life |
| 16 May 2025 | 53.8 | Installed | Diego Ramón Sarrió Cucarella, M. Afr. | Bishop of Laghouat, Algeria |
| 21 May 2025 | 76.9 | Retired | Salvador Giménez Valls | Bishop of Lleida | Bishop Emeritus |
| 52.4 | Appointed | Daniel Palau Valero | Bishop of Lleida |
| 24 May 2025 | 69.6 | Installed | Jesús Fernández González | Bishop of Córdoba |
| 31 May 2025 | 48.1 | Succeeded | Josep-Lluís Serrano Pentinat | Bishop of Urgell |
| 75.8 | Retired | Joan Enric Vives Sicilia | Bishop of Urgell | Bishop Emeritus |
| 14 Jun 2025 | 67.9 | Ordained Bishop | Pedro Aguado Cuesta, Sch. P. | Bishop of Huesca |
| 81.3 | Ceased | Vicente Jiménez Zamora | Apostolic Administrator of Huesca | Archbishop Emeritus of Zaragoza |
| 15 Jun 2025 | 67.9 | Installed | Pedro Aguado Cuesta, Sch. P. | Bishop of Jaca | Bishop of Huesca |
| 81.3 | Ceased | Vicente Jiménez Zamora | Apostolic Administrator of Jaca | Archbishop Emeritus of Zaragoza |
| 27 Jun 2025 | 75.5 | Retired | Jesús Esteban Catalá Ibáñez | Bishop of Málaga | Bishop Emeritus |
| 57.3 | Appointed | José Antonio Satué Huerto | Bishop of Málaga |
| 9 Jul 2025 | 61.4 | Appointed | Abilio Martínez Varea | Bishop of Ciudad Real |
| 76.7 | Retired | Gerardo Melgar Viciosa | Bishop of Ciudad Real | Bishop Emeritus |
| 19 Jul 2025 | 52.6 | Ordained Bishop | Daniel Palau Valero | Bishop of Lleida |
| 13 Aug 2025 | 93.6 | Died | Cipriano García Fernández, O.S.A. † | Prelate Emeritus of Cafayate, Argentina |
| 13 Sep 2025 | 57.6 | Installed | José Antonio Satué Huerto | Bishop of Málaga |
| 15 Sep 2025 | 64.9 | Appointed | Piero Pioppo | Apostolic Nuncio to Spain |
| 64.9 | Appointed | Piero Pioppo | Apostolic Nuncio to Andorra | Apostolic Nuncio to Spain |
| 1 Oct 2025 | 50.1 | Died | José Antonio Álvarez Sánchez † | Auxiliary Bishop of Madrid |
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